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The pharmacologic effects of zidovudine may be lowered because of enhanced non-hepatic or renal clearance of zidovudine.

Evaluate patients for signs of diminished diuresis and/or effects on blood pressure and improve the dosage of the diuretic as wanted.

Keep track of for signs of opioid withdrawal. If a CYP3A4 inducer is discontinued, consider oxycodone and acetaminophen tablets dosage reduction and check for signs of respiratory despair.

Because oxycodone is extensively metabolized during the liver, its clearance might lower in patients with hepatic impairment. Initiate therapy in these patients with a lower than usual dosage of PERCOCET and titrate carefully.

Check patients carefully for respiratory melancholy, Specially within the first 24 to 72 hours of initiating therapy and pursuing dosage boosts with oxycodone and acetaminophen tablets and change the dosage accordingly [see WARNINGS].

If far too much of this medicine is taken for your long time, it might turn out to be habit-forming and cause psychological or Bodily dependence. Also, big quantities of acetaminophen may well cause liver damage if taken for the long time.

These effects could be additional pronounced with concomitant use of oxycodone and acetaminophen tablets and CYP3A4 and CYP2D6 inhibitors, significantly when an inhibitor is additional after a secure dose of oxycodone and acetaminophen tablets is reached [see WARNINGS].

Opioid antagonists, which include naloxone, are specific antidotes to respiratory depression resulting from opioid overdose. For clinically significant respiratory or circulatory despair secondary to opioid overdose, administer an opioid antagonist. Because the duration of opioid reversal is predicted to be significantly less than the duration of action of oxycodone in oxycodone and acetaminophen tablets, carefully keep an eye on the patient until eventually spontaneous respiration is reliably reestablished.

To browse the Patient Information (or other instructional substance) that could appear with their naloxone. Emphasize the importance of performing this before an opioid emergency comes about, And so the patient and caregiver will know what to try and do. Accidental Ingestion

Opioid analgesics, such as oxycodone and acetaminophen tablets, can prolong labor by actions which briefly decrease the strength, duration, and frequency of uterine contractions. Nevertheless, this effect is not dependable and will be offset by an increased level of cervical dilation, which has a tendency to shorten labor. Keep an eye on neonates exposed to opioid analgesics during labor for signs of surplus sedation and respiratory depression.

When you have a feeding tube, the extended-release capsule contents is usually poured into your tube. Check with your health care provider how you'll want to take the medication and follow these Instructions carefully.

If urgent utilization of an opioid is essential, use test doses and Regular titration of little doses to treat pain while intently monitoring blood pressure and signs and symptoms of CNS and respiratory depression.

This medication may be prescribed for other uses; request your doctor or pharmacist for more information.

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